The CBOE's website became unavailable just as it launched its first bitcoin futures contracts on Sunday.
The world's largest bitcoin exchanges are reporting significantly varying prices as the cryptocurrency's price soars to new all-time highs.
The price of bitcoin is spiking, climbing above $7,700 for first time since Nov. 8.
CME chairman and CEO Terry Duffy has said that the derivatives exchange operator could list a planned bitcoin futures product as early as next month.
Goldman Sachs is said to be in the early stages of planning a possible cryptocurrency trading operation, according to the Wall Street Journal.